Therapy of Plasmodium falciparum parasitemia with desferrioxamine [letter; comment]
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چکیده
منابع مشابه
Therapy of Plasmodium falciparum parasitemia with desferrioxamine.
Recently Gordeuk et all have observed a drastic increase of the rate of parasite clearance in patients with asymptomatic Plasmodium falcipanun infection. They suggested that this may be partially caused by limitation of iron by chelation, although they argued that this may not be the only mechanism limiting growth of P falcipanun. Previous studies have shown elevated levels of neopterin in urin...
متن کاملIron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia.
To determine if iron chelation therapy has activity against human malaria, we administered desferrioxamine B in amounts of 100 mg/kg per day by continuous 72-hour subcutaneous infusions to 28 volunteers with asymptomatic Plasmodium falciparum infection in a randomized, double-blind, placebo-controlled crossover trial. Peripheral blood concentrations of P falciparum ring forms were determined at...
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Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pre...
متن کاملEffect of Plasmodium falciparum parasitemia on erythrocyte zinc protoporphyrin.
References 1. Cryer PE, Haymond MW, Santiago JV, Shah SD. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 1976;295:573–7. 2. Filozof C, Fernandez Pinilla MC, Fernandez-Cruz A. Smoking cessation and weight gain. Obes Rev 2004;5:95–103. 3. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a ...
متن کاملContinuation of chloroquine-susceptible Plasmodium falciparum parasitemia in volunteers receiving chloroquine therapy.
Volunteers infected with a chloroquine-susceptible line of Plasmodium falciparum were administered standard oral chloroquine therapy at the first detection of parasites in the blood. Parasitemias progressed in the face of therapy for up to 5 days and to levels up to 100-fold greater than those at the initiation of treatment. Thereafter, infections cleared without a requirement for additional ch...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v80.3.843.843